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BrainDS + PET · Signal

PET signal, measured on the patient’s own anatomy.

BrainDS + PET is an optional BrainDS module. It aligns brain PET to the same patient’s T1-weighted MRI, measures uptake region by region as SUVR, and compares it with reference data for each tracer — so structure and signal are reviewed together.

Optional module · Research use only: Available now for research use only. Not yet approved as a medical device by MFDS (KFDA), the FDA or CE — not for clinical or diagnostic use.

  • Brain PET + 3D T1 MRI
  • FDG · Amyloid · Tau
  • Regional SUVR
  • Cerebellar reference
  • English · Korean
BrainDS + PET evaluation window with amyloid PET fused over MRI, region visibility and overlay controls, with patient details masked
BrainDS + PET FDG report summary page with segmentations, key metrics and a regional cortical summary, with patient details masked
Fig. 01BrainDS + PET viewer (amyloid PET) with an FDG report summary page. Sample cases from public research data (ADNI); personal details masked and automated interpretation text blurred.
01 / Rationale

Why pair PET with MRI?

Structural MRI and PET answer different questions. Measuring both on one segmentation ties every PET value to a named region of the same brain.

MRI · Structure

How much tissue is there

Structural MRI measures the size and shape of brain regions — the basis of BrainDS volumetry.

PET · Signal

What the tissue is doing

PET images a radiotracer, showing processes such as glucose metabolism or protein deposition that may change before structural loss is visible.

BrainDS + PET

Both, on one map

PET is sampled inside the regions of the patient’s own BrainDS segmentation, so structure and signal can be read region by region.

02 / Workflow

From paired scans to a PET report

PET analysis reuses the BrainDS segmentation of the same patient.

  1. 01

    Pair

    Select a brain PET study and a matching 3D T1-weighted MRI of the same patient. The tracer is recognised from the DICOM metadata.

  2. 02

    Segment

    BrainDS segments the T1 scan into its 95 regions — the same map used for structural analysis.1

  3. 03

    Align

    The PET volume is registered to the patient’s own T1 scan, and a check image confirms the alignment.

  4. 04

    Quantify

    Regional and composite SUVR are calculated with the cerebellar cortex as the reference region, then compared with reference data for the tracer as Z-scores, percentiles and percentage differences.

  5. 05

    Report

    An eight-page PET report in English or Korean, with fused PET–MRI views and longitudinal trends when earlier PET studies exist.

03 / Tracers

Tracer-aware quantification

Each tracer gets its own summary measures and its own reference data.

FDG

Glucose metabolism

  • Composite SUVR over Alzheimer’s-relevant regions
  • Z-score and % difference versus reference data
  • Lobe-level cortical summary

Amyloid

Florbetapir

Amyloid deposition

  • Global cortical SUVR
  • Z-score and % difference versus reference data
  • Left and right regional SUVR tables

Tau

Flortaucipir

Tau deposition

  • Composite SUVR for Braak regions I–II, III–IV and V–VI
  • Z-score and % difference versus reference data
  • Left and right regional SUVR tables

Tracer support is confirmed for each research project.

04 / Capabilities

Review signal and structure together

The same study list, viewer and report format as BrainDS.

BrainDS + PET regional cortical summary table with SUVR, Z-score and percentage difference beside colour-mapped cortical views
Fig. 02Regional cortical summary for an FDG study — SUVR, Z-score and % difference by region. Public research data (ADNI).

Regional summary at a glance

Each study is summarised by region — SUVR, Z-score and percentage difference — beside colour-mapped cortical views, with full left–right tables behind it.

  • SUVR, Z-score and % difference by region
  • Colour-mapped cortical views
  • Regional tables with reference ranges
BrainDS + PET longitudinal chart of regional SUVR across three PET study dates
Fig. 03PET longitudinal view — regional SUVR across visits with the reference band shaded. Public research data (ADNI).

Follow PET over time

When earlier PET studies exist, BrainDS + PET charts regional SUVR or percentile across visits against the reference band.

  • Longitudinal SUVR and percentile charts
  • Same regions as the structural trends
  • CSV and PNG export
BrainDS + PET viewer with FDG PET fused over MRI, opacity, brightness and contrast controls, and axial, coronal and sagittal views
Fig. 04MRI/PET view with overlay controls. Public research data (ADNI).

Fused PET–MRI viewer

Review PET over the patient’s MRI in three planes. Adjust PET and segmentation opacity, brightness and contrast, or switch to contours only.

  • PET overlaid on T1 MRI in three planes
  • Independent PET and segmentation opacity
  • Region visibility by lobe

One installation

PET runs inside the same on-premise BrainDS installation — no separate platform to deploy, secure or learn.

  • Shared study list and viewer
  • Same report format and languages
  • Images stay inside your network
05 / Report

Inside the PET report

Sample pages from the eight-page PET report: tracer summaries, regional PET intensity maps with SUVR tables, and a plain-language region guide.

FDG summary page of the BrainDS + PET report with segmentations, key metrics and a regional cortical summary
Fig. 05FDG summary page
Tau summary page of the BrainDS + PET report with Braak-stage composite metrics and regional cortical views
Fig. 06Tau summary page
BrainDS + PET report page with regional PET intensity maps and a table of regional SUVR with reference ranges
Fig. 07Regional PET intensity and SUVR
BrainDS + PET report page with a labelled 3D cortical region map and plain-language region cards
Fig. 08Region guide

Sample pages from public research data (ADNI). Identifiers are removed and automated interpretation text is blurred.

06 / Specifications

Specifications

Inputs
Brain PET (DICOM) with a matching 3D T1-weighted MRI
Tracers
FDG · amyloid (florbetapir) · tau (flortaucipir)
Anatomy
BrainDS segmentation, 95 regions
Registration
PET to the patient’s own T1 MRI, with a check image
Measures
Regional and composite SUVR (cerebellar cortex reference) · Z-score, percentile, % difference
Outputs
Fused PET–MRI viewer · 8-page PDF (EN/KO) · longitudinal charts
Requires
BrainDS
Deployment
On-premise, within the BrainDS installation
Status
Optional module · available now · research use only · not yet approved as a medical device
07 / Publications

Peer-reviewed research

Studies by researchers at MTechLab and Gachon University. Results describe the cohorts studied; they are not claims about BrainDS product performance.

  1. First page of the article “Regional Brain Volume Changes Across Adulthood: A Multi-Cohort Study Using MRI Data”, Brain Sciences, 2025

    [1] Brain Sciences · 2025

    Regional brain volume changes across adulthood: a multi-cohort study using MRI data

    Shim JH, Baek HM, Hoon J · 15(10):1096

    Read the article
08 / FAQ

FAQ

Which PET tracers are supported?

BrainDS + PET recognises FDG, amyloid (florbetapir) and tau (flortaucipir) PET from the DICOM metadata. Tracer support is confirmed for each research project.

Why is a T1-weighted MRI required?

PET is aligned to the patient’s own T1 scan so that uptake is measured inside regions defined by the BrainDS segmentation of that same brain.

Which reference region is used for SUVR?

The cerebellar cortex of both hemispheres.

Is BrainDS + PET a separate product?

No. It is an optional module that runs inside a BrainDS installation and shares its study list, viewer and report format.

Is it approved for clinical use?

No. BrainDS + PET is available for research use only. It has not yet been approved as a medical device by MFDS (KFDA), the FDA or CE.

Add signal to structure

Talk to us about BrainDS + PET for your nuclear-medicine or research imaging team.